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Lawrenceville, NJ (Charles B Simone, M.MS., M.D.) – There are 81 separate studiesinvolving a combined 128,000 participants — that demonstrated an average efficacy of 65% for several different outcomes.  There are also 22 studies involving nearly 40,000 people — around the outcome in question, hospitalization. Those studies showed an average efficacy of 39%.

The World Health Organization – Swiss Policy Research – sponsored a review of 11 randomized trials involving 1456 patients that shows ivermectin, a safe prescription drug, saves lives – an 83% reduction in dying from COVID-19.  There are 45 more trials ongoing with 7100 patients. 

Ivermectin also has anticancer effects.


Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance.

In summary, based on the totality of the trials and epidemiologic evidence presented in this review along with the preliminary findings of the Unitaid/WHO meta-analysis of treatment RCTs and the guideline recommendation from the international BIRD conference, ivermectin should be globally and systematically deployed in the prevention and treatment of COVID-19.

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19.


Ivermectin and Hydroxychloroquine are lysosomotropic agents that should be used within the first five days of exposure to SARS-CoV 2 (COVID-19).  These medicines cross the lysosomal membrane and become protonated thus increasing the lysosome’s pH (alkaline) rendering the lysosome nonfunctional.  These medicines include Hydroxychloroquine and Ivermectin. 



Ivermectin for Prevention and Treatment of COVID-19 Infection:

A Systematic Review, Meta-analysis, and Trial
Sequential Analysis to Inform Clinical Guidelines


In this meta-analysis of 15 trials ivermectin reduced the risk of death compared with no ivermectinModerate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. 

Ivermectin prophylaxis reduced COVID-19 infection by an average 86%

Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.

This result was confirmed in a trial sequential analysis using the
same DerSimonian–Laird method that underpinned the unadjusted analysis. This was also robust against a trial sequential analysis using the Biggerstaff–Tweedie method.

Ivermectin for Prevention and Treatment of COVID-19 Infection.
Bryant et alAmerican Journal of Therapeutics: June 17, 2021 – Volume Publish Ahead of Print – Issuedoi: 10.1097/MJT.0000000000001402




In another study published January 15, 2022 done in Itajaí, Santa Catarina, Brazil regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates. 

Of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 subjects were included in the analysis: 113,845 (71.3%) regular ivermectin users and 45,716 (23.3%) non-users. Of these, 4,311 ivermectin users were infected, among which 4,197 were from the city of Itajaí (3.7% infection rate), and 3,034 non-users (from Itajaí) were infected (6.6% infection rate), with a 44% reduction in COVID-19 infection rate (risk ratio [RR], 0.56; 95% confidence interval (95% CI), 0.53-0.58; p < 0.0001). Using PSM, two cohorts of 3,034 subjects suffering from COVID-19 infection were compared. The regular use of ivermectin led to a 68% reduction in COVID-19 mortality (25 [0.8%] versus 79 [2.6%] among ivermectin non-users; RR, 0.32; 95% CI, 0.20-0.49; p < 0.0001). When adjusted for residual variables, reduction in mortality rate was 70% (RR, 0.30; 95% CI, 0.19-0.46; p < 0.0001). There was a 56% reduction in hospitalization rate (44 versus 99 hospitalizations among ivermectin users and non-users, respectively; RR, 0.44; 95% CI, 0.31-0.63; p < 0.0001). After adjustment for residual variables, reduction in hospitalization rate was 67% (RR, 0.33; 95% CI, 023-0.66; p < 0.0001).




The Egyptian trial showed the strongest treatment effects: 5 days of 0.4 mg/day (28 mg per day for a 70 kg person 154 lb) compared to the Bangladesh trial of 1 day of 0.2 mg/day (14 mg per day for a 70 kg person 154 lb). Cost in U.S is $75 for 50 tablets each containing 3 mg; and far less costly in Bangladesh.

Ivermectin is an anti-parasite medicine used for more than 40 years. It is on the WHO’s list of essential medicines, has been given 3.7 billion times around the globe, and won the Nobel prize for its global and historic impacts in eradicating human endemic parasitic infections. Ivermectin inhibits SARS-CoV-2 replication and suppresses inflammation. It also seems to be safe for people with Myasthenia Gravis, whereas Hydroxychloroquine is not.


Dr. Pierre Kory testifies to Senate Committee about Ivermectin, Dec. 8, 2020


   Preprint Manuscript https://osf.io/wx3zn/



1) MEDIA –

New York Times – “Senate hearing promoted unproven drugs and dubious claims about ivermectin.”

AP – “No evidence ivermectin is a miracle drug against COVID-19”


YouTube, owned by Google – banned ivermectin information from Dr Risinger and Dr. Martenson.

Twitter – blacklisted European Medical Journal for published study on ivermectin. 

Facebook – removed posts of Front Line Covid-19 Critical Care

3) NIH – formed a panel of doctors who decided what  treatments can be given to patients. Ivermectin was not on the list and, in fact, the panel recommended  use Remdesivir as highly recommended by Fauci –  “diminishes the time to recovery.” Midway through the study, the endpoint was changed from mortality to recovery because Remdesivir does not save lives.  The World Health Organization does not recommend it at all.  Gilead owns Remdesivir.  Seven members of the panel are paid by Gilead, including the three co-chairs of the panel who choose the panel members.

August 8, 2020 – India Times – Ivermectin to be used for Covid treatment in Uttar Pradesh (a state in India with 230 million people) as a new medication for the treatment and prevention of Covid-19. In January 2021, fewer than 10 deaths a days while in the U.S. there were more than 3,000 deaths per day.



El Salvador government gives this package that includes ivermectin to its citizens with COVID-19 or those who are exposed to people with COVID-19. Video is from BitChute.

To obtain Ivermectin call your own physician or one listed by Front Line COVID-19 Critical Care Alliance at

The following list of pharmacies will fill prescriptions for ivermectin  https://covid19criticalcare.com/pharmacies/

WSJ Misleads Public on Ivermectin, Ignores Latest Revelations About ‘Hidden Author’ Who Undermined Its Efficacy

When Lawrie confronted a squirming Hill, Hill eventually admitted the conclusions in his analysis had been influenced by Unitaid, a quasi-governmental advocacy organization funded by the Bill & Melinda Gates Foundation.  Unitaid gave $40 million to Andrew Hill’s employer, the University of Liverpool, four days before the publication of Hill’s study. Hill confessed that the sponsors were pressuring him to influence his conclusion.


Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.


© 2021 Charles B. Simone, M.MS., M.D.