We do not diagnose disease or recommend a treatment protocol or dietary supplement for the treatment of disease. You should share this information with your physician who can determine what nutrition and disease treatment regimen is best for you.  Ask your physician any questions you have concerning your medical condition.

You can search this site or the web for topics of interest that I may have written (use Dr Simone and topic).

“We provide truthful information without emotion or influence from the medical establishment, pharmaceutical industry, national organizations, special interest groups or government agencies.”  Charles B Simone, M.MS., M.D.



This is an overview of Dr Simone Protocol.  Print the pdf file below this picture.


pdf file that you can download and print DR SIMONE PROTOCOL


We do not diagnose disease or recommend a treatment protocol or dietary supplement for the treatment of disease. You should share this information with your physician who can determine what nutrition and disease treatment regimen is best for you.  Ask your physician any questions you have concerning your medical condition.

Detoxify the spike protein by preventing the attachment of spike protein to the ACE2 receptors 

Hydroxychloroquine, Ivermectin, and chloroquine can prevent the spike protein from binding to the ACE2 receptors thus preventing the spike protein or the entire virus to gain entry into the target cells (1,2,3)These agents also can bind to any circulating spike protein before it binds any ACE2 receptors (4,5,6).   Suramin, catechin, curcumin can also bind the spike protein. If the ACE2 receptor is already bound, the COVID virus cannot enter the cell (7). Hydroxychloroquine, Ivermectin, and chloroquine act as ionophores to promote intracellular accumulation of zinc that is needed to kill/inactivate any intact virus particles that might still be present. 

Many nutrients shown below can neutralize downstream toxicity



1) ORALPHARYNX / SINUS TREATMENT HYGIENE – THIS IS NUMBER ONE PRIORITY because viruses and bacteria enter your body via the oropharynx.  Keep sinus exit ports open to promote mucus flow from the sinuses so that viruses and bacteria can’t swim up and lodge in your sinuses.  You can do this any time and any place inexpensively. All the different flushes below are particularly useful if you feel congested, start to feel a sore throat, feel achy, have been in a crowd or in a high traffic and poorly ventilated room. SINUS HYGIENE DECREASES VIRAL INFECTION



Imagine yourself trying to swim up these or any other waterfalls. It is not possible.  So promote mucus flow so that viruses and bacteria can’t swim up and lodge in your sinuses.

1) NASAL SALINE FLUSHES every 30 to 45 minutes – this has antiviral effects (https://www.nature.com/articles/s41598-018-37703-3) and promotes mucus flow so that viruses and bacteria can’t lodge.  Insert the spray tip in the nostrils perpendicular to the face and direct it toward the ears to get the spray to the exit ports to open them.



2) 6-8 NASAL DROPS OF 1% POVIDONE IODINE every 4 hours.  If you can’t find a 1% solution, make a dilution from the more commonly found 10% solution over-the-counter.  Dilute the 10% Povidone Iodine solution by adding 2 tablespoons (30 ml) of it into a full glass of water (300 ml distilled, sterile, or boiled). This will make approximately 1% so it can be used as a mouth rinse or nasal spray.  Then put 6 drops of this 1% solution onto each nostril floor, tilt head backward, and allow the drops to trickle down to back of throat and base of tongue (8,9,10).  Don’t eat or drink for 30 minutes because that would dilute/wash away the iodine. Not pleasant, but effective. Do not use for more than 5 days if pregnant.

3) Gargle with Hydrogen Peroxide

4) Even very dilute Bleach has been used by dentists – several drops in 6 ounces of water (11,12,13).

5) Steam (10 min every 4 hours) – boil an inch of water in a quart size pot, take it away from the stove, add about 10 drops of Eucalyptus oil, and inhale over the pot with a towel over your head. 

6) Oxymetazoline nasal spray has antiviral effects and is not a banned substance (over-the-counter) (14).  Use as directed. 

7) Prescription steroid nasal spray to keep inflammation down – this requires a Therapeutic Use Exemption approval during sports competitions. Insert the spray tip in the nostrils perpendicular to the face and direct it toward the ears to get the medicine to the exit ports to open them.

8) Hydrate to keep the mucus thin and flowing

2) HYDROXYCHLOROQUINE (HCQ) 200 mg twice a day for 5 to 10 days.  FDA considers hydroxychloroquine safe in pregnancy. HCQ can be taken in place of IVERMECTIN or together with IVERMECTIN.



3) IVERMECTIN dosing (1,15,16).  Ivermectin also has anti-inflammatory and anti-viral effects.  

0.4 – 0.6 mg/kg once a day with meals for 5 days or until symptoms resolve. [1 kg = 2.2 pounds].  Ivermectin comes in 3 mg tablets.

After 5 days, change to once or twice weekly depending on the time to symptom recurrence/persistence. Discontinue after 2–4 weeks if all symptoms have resolved and do not recur.

Do not use if you are taking Warfarin or are pregnant or lactating 

To obtain Ivermectin call your own physician or one listed by Front Line COVID-19 Critical Care Alliance at https://covid19criticalcare.com/providers/

The following list of pharmacies will fill prescriptions for ivermectin  https://covid19criticalcare.com/pharmacies/

myfreedoctor.com “We have a team of volunteer doctors that donate their time freely to help treat patients. Dr. Ben Marble is the founder of myfreedoctor.com, an online medical consultation service.

4) ANTI-INFLAMMATORIES like prednisone, budesonide, aspirin, omega 3 fatty acids, colchicine. Do not use ibuprofen (https://bit.ly/2J1YJW6).

PREDNISONE – This is a prescription medicine that may increase appetite, raise blood glucose. 

Days 1-5:  20 mg twice a day with food (second dose no later than 4PM to avoid sleeplessness)

Days 5-10: 20 mg in morning with food

Days 11-15: 10 mg in morning with food

Use the high dose when breathing is getting more difficult or there is lung dysfunction or there is need for oxygen – steroids are critical and  lifesaving.

BUDESONIDE ampules containing 0.2 mg/2 ml or 0.4 mg/2 ml inhaled with nebulizer. A nebulizer that plugs into the wall is more effective than a battery operated one.   Budesonide nasal spray also.  This is a prescription medicine that reduces the risk of needing urgent medical care and reduced the time to recovery after early COVID-19.

ASPIRIN – 325 mg uncoated aspirin taken with the largest meal each day (has anti-platelet and anti-clotting properties). For massive or large volume clots, some physicians use surgery, apheresis, and dialysis.


OMEGA 3 FATTY ACIDS4 softgels per day with food each containing about EPA 500 mg + DHA 400 mg

5) ANTIOXIDANTS in moderate to high doses, in the correct doses, correct chemical form, and correct ratio of one to another, as well as Vitamin B6 (has anti-thrombosis properties) –  Consider Protector ONCCOR https://bit.ly/3nuTHo6.

6) ALKALINE pH– a high alkaline pH is important because acid allows the spike protein/virus to attach to the ACE2 receptors.  Alkaline pH minimizes this attachment.  The function of the stomach is to digest food and liquid by secreting mainly hydrochloric acid.  So even though you may think that alkaline vegetables and expensive “alkaline water” will help you, they do not because of the powerful stomach hydrochloric acid.  Consider SIMONE SUPER ENERGY that has a buffered alkaline bicarbonate base pH.  https://www.simonesuperenergy.com/

7) OTHER NUTRIENTS and medicines 

ZINC – 50 mg tablet per day with food and multiple ZINC OXIDE lozenges/day

N-ACETYL CYSTEINE600 mg twice a day with food.

VITAMIN C2000 to 4000 mg each day with food.

VITAMIN D3 – 125 mcg (5,000 IU) per day with food.

QUERCETIN500 mg twice per day (if taking Ivermectin, take Quercetin one hour before or after Ivermectin)

CoQ10 – 200 mg twice a day with food

FAMOTIDINE20 mg per day (over-the-counter Pepcid)

SPIRONOLACTONE – to be used for severe cases – 100 mg twice a day for ten days – it is a prescription diuretic medicine and is a potent antiandrogen at doses above 100 mg a day.  Androgens increase viral replication and inflammation.

Polyphenols in the diet have antioxidant, anti-inflammatory and immunomodulatory properties can be helpful:

Epigallocatechin-3-gallate (EGCG): from tea leaves

Punicalagin: The most abundant polyphenol in pomegranate

Resveratrol: fresh from vegetables and fruits

Curcumin: found in turmeric

Close to 80% of patients have prolonged illness after COVID-19 infection – the long haulers.  These complications are generally seen in those who had mild to moderate infections and in young adults who did not need respiratory support.  And some who receive the vaccine have similar complications.  

Spike proteins from Covid-19 infection and/or spike proteins made from the vaccine can cause inflammation and organ dysfunction when they bind to the ACE2 docking sites on human cells of the Mucus Membranes, Eye, Respiratory Tract, Heart / Blood Vessels, Brain, Musculoskeletal, Gastrointestinal, Kidney, Skin.

The spike also binds to and renders the p53 gene ineffective.  The p53 gene is a tumor suppressor gene that stops the formation of tumors.

This binding to organs occurs before antibodies are made to the spike proteins.

The shots cause the recipient to create trillions of spike proteins that: 

(1) do not remain in the local shoulder injection but travel in the blood and in virtually all organs of the body.

(2) are pathogenic (disease causing) attaching to endothelial, pulmonary and other cells, forming clots and attacking heart cells.

(3) together with their lipid nanoparticles cross the blood brain barrier, with unknown long-term effects on the brain and high concern for chronic neurodegenerative disorders.

(4) interact in many signaling pathways which may trigger tumor formation, cancer, and other serious diseases.

(5) accumulate in reproductive organs and spleen raising serious long-term concerns.  

The more ACE2 receptors there are in a person, the more spike proteins get attached leaving fewer spike proteins freely available to make antibodies.  That’s why people who take certain medicines and/or have certain risk factors have a blunted immune response to the vaccine but still can have inflammation and organ dysfunction (17,18).

A person may experience any of the following:

Mucus membranes: Running nose, sneezing, burning and itchy eyes. 

Respiratory Tract: shortness of breath, congestion, pneumonia, persistent cough, etc.

Heart / Blood Vessels: myocarditis, heart attack, chest pain, arrhythmias, blood pressure changes, blood clotting, etc.

The spike protein attaches to the sialic acid residues of red blood cells, causing red cell clumping and starts the coagulation cascade.  Routine blood tests to detect clotting, like D-dimer, may or may not be elevated.   

Most individuals with myocarditis do not have any symptoms. Complications of myocarditis include dilated cardiomyopathy, arrhythmias, sudden cardiac death and carries a mortality rate of 20% at one year and 50% at 5 years. According to the National Center for Biotechnology Information, U.S. National Library of Medicine, “despite optimal medical management, overall mortality has not changed in the last 30 years.” 

COVID 19 can cause heart attack, myocarditis, abnormal QRS axis in 20%, conduction abnormalities in 20%, premature beats in 10%, atrioventricular block in 2.5%, ST and T wave changes, 9.3% have arrhythmias, mostly atrial fibrillation.

mRNA COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and Acute Coronary Syndrome Risk as Measured by the PULS Cardiac Test. “We conclude that the mRNA vaccines dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination.”  https://www.ahajournals.org/doi/abs/10.1161/circ.144.suppl_1.10712

Brain (19): ‘Leaky’ Blood-Brain Barrier (BBB), brain fog or difficulty concentrating, loss of smell, malaise, fatigue, headaches or migraines that come on suddenly become worse with standing and get more severe as the day progresses, depression, insomnia, vertigo, panic attacks, tinnitus, etc.  ADD / ADHD / Autism spectrum disorders.  If the BBB is damaged or weakened in some way, immune cells are able to cross and attack the myelin around your nerves, which leads to nerve damage and MS symptoms. 

Musculoskeletal: muscle and joint pain, chronic fatigue that does not improve with rest, weakness, inability to exercise, unable to perform normal activities.

Gastrointestinal: Anorexia, diarrhea, bloating, vomiting, nausea, etc.

Skin: Itching, rashes, hair loss.

Cancer: Higher risk because the spike also binds to and renders the p53 gene ineffective.  The p53 gene is a tumor suppressor gene that stops the formation of tumors.


A natural COVID-19 infection provides both systemic protection (IgG antibodies and cellular activation) as well as protection in the nasal passages and respiratory tree (IgA antibodies).  The vaccines do not provoke IgA antibody production and therefore do not provide protection in the nasal passages and respiratory tree.  That is why there are so many cases of breakthrough infections in those who have been fully vaccinated and that is why fully vaccinated people can harbor the virus in their nasal passages that can potentially be spread to others.


1. Lehrer and Rheinstein, 2020; Ivermectin docks to the SARS-CoV-2 spike receptor-binding domain attached to ACE 2. In Vivo 34:3023-3026. PMID: 32871846

2. Wang N, Han S, Liu R et al. (2020) Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV spike pseudotyped virus. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 79:153333. PMID: 32920291

3. Eweas A, et al (2021) Molecular docking reveals ivermectin and remdesivir as potential repurposed drugs against SARS-CoV-2. Frontiers in Microbiology 11:592908. PMID: 33746908

4. Fantini et al., 2020. Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection. International Journal of Antimicrobial Agents 55:105960. PMID: 32251731

5. Sehailia and Chemat, 2021.  Antimalarial-agent artemisinin and derivatives portray more potent binding of Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19. Journal of Biomolecular Structure & Dynamics 39:6184-6194. PMID: 32696720

6. Saha and Raihan, 2021. The binding mechanism of ivermectin and levosalbutamol with spike protein of SARS-CoV-2. Structural Chemistry Apr 12. Online ahead of print. PMID: 33867777

7. Pillay,T (2020) Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein. Journal of Clinical Pathology 73:366-369. PMID: 32376714

8. Povidone Iodine (PVP-I) Oro-Nasal Spray: An Effective Shield for COVID-19 Protection for Health Care Worker (HCW), for all  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026810/

9. Effect of 1% Povidone Iodine Mouthwash/Gargle, Nasal and Eye Drop in COVID-19 patientfile:///C:/Users/mail/Downloads/176-Article%20Text-335-2-10-20210102.pdf

10. In vitro efficacy of a povidone iodine nasal antiseptic for rapid inactivation of SARS CoV-2. https://pubmed.ncbi.nlm.nih.gov/32940656/

11.The American Dental Association Council on Dental Therapeutics has designated 0.1% sodium hypochlorite a ‘mild antiseptic mouth rinse’ and suggested its use for direct application to mucous membranes. Dilute sodium hypochlorite has no contraindications. Its high degree of safety permits frequent and broad usage by both dentists and patients.

12.Effects of 0.05% sodium hypochlorite oral rinse on supragingiival biofilm and gingival inflammation https://www.sciencedirect.com/science/article/pii/S0020653920332937

13. Sodium hypochlorite (dilute chlorine bleach) oral rinse in patient self-care  https://pubmed.ncbi.nlm.nih.gov/26856131/

14. https://journals.sagepub.com/doi/10.2500/ajra.2010.24.3491

15. FLCCC Alliance   https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/

16. Zaidi AK, Dehgani-Mobaraki P.  The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article.  The Journal of Antibiotics. 15 June 2021.   https://www.nature.com/articles/s41429-021-00430-5#citeas

17. Central obesity, smoking, and hypertension are associated with a blunted antibody response to COVID-19 mRNA vaccine  https://www.medrxiv.org/content/10.1101/2021.04.13.21255402v1


19. Ramirez et al. Neurobiology of Disease. Vol 146. Dec 2020.https://www.sciencedirect.com/science/article/pii/S096999612030406X?via%3Dihub

© 2021 Charles B Simone, M.MS., M.D.