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Lawrenceville, NJ (Charles B Simone, M.MS., M.D.) – Our plan for How To Open Schools.

1) Starting in ninth grade separate the female students from the male students. 

Put 25% more females in an all female classroom and 25% fewer males in an all male classroom.

COVID-19 (SAR-CoV-2) affects more adults than children and more males than females. At age 15 or so, males begin to have more ACE2 compared to females.  Estrogen suppresses the renin-angiotensin system and therefore results in fewer ACE2 molecules for females.

(https://academic.oup.com/cardiovascres/article/53/3/672/327796  Renin angiotensin system and gender differences in the cardiovascular system)

COVID-19 attaches and infects cells that have ACE2 receptors (heart, lung, intestine, kidney, eye, blood vessels). During infection an enzyme (ADAM-17) can cleave off the cell’s membrane ACE2 resulting in shedding of  ACE2 in the blood (soluble ACE2).  Soluble ACE2 can reflect the amount of cell membrane ACE2.  The more ACE2, the more infection.    https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-020-02942-2

2) All children wear facial shields primarily and masks as well most of the time.  Medically certified asthmatics will need some time without masks. 


3) All children frequently use safe hand sanitizer. 

4) All desks are to have plastic panels surrounding three sides of the desk


5) Schools should upgrade to MERV 13 or better air filters to filter out viruses according to the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE).


6) Follow CDC Guidelines for Preparing K-12 School Administrators for a Safe Return to School in Fall 2020   https://www.cdc.gov/coronavirus/2019-ncov/community/schools-childcare/prepare-safe-return.html

 protectionhat, antiuvhat, faceshield, antifog

© 2020 Charles B. Simone, M.MS., M.D.