5/12/16

We do not diagnose disease or recommend a dietary supplement for the treatment of disease. You should share this information with your physician who can determine what nutrition, disease and injury treatment regimen is best for you.  You can search this site or the web for topics of interest that I may have written (use Dr Simone and topic).  

“We provide truthful information without emotion or influence from the medical establishment, pharmaceutical industry, national organizations, special interest groups or government agencies.”  Charles B Simone, M.MS., M.D.

TELOMERES, ANTI-AGING, SIMONE TEN POINT PLAN

Lawrenceville, NJ (Dr Simone) – In 1980 I wrote Cancer and Nutrition, A Ten Point Plan to Reduce Your Risk of Getting Cancer.  This was the first in its genre. Our Ten Point Plan reviews lifestyle factors you need to modify to decrease your risk of cancer and heart disease. And now with this new information about telomeres, the very same Simone Ten Point Plan can help you slow the progression of aging.  
 
Telomeres are DNA-protein structures found at each end of each chromosome. They protect and preserve your genetic information (genome) from degradation and negative changes.  However, a small amount of this telomere DNA is lost with each normal cell division, thus shortening the telomere that leads to progressive aging, cancer, heart disease, and/or cell death (apoptosis).  

  • Telomere length shortens with age.

  • Lifestyle factors such as obesity, smoking, lack of physical activity, stress, exposure to pollution, etc. cause telomeres to shorten more quickly, increase cancer risk, and accelerate the pace of aging.

  • Dietary calorie restriction, appropriate diet (low fat, high fiber, plenty of antioxidants, omega-3 fatty acids, lean/low protein), regular exercise (Science AdvancesJul 2016:2(7) e1600031), and stress modification can reduce the rate of telomere shortening, disease risk, and pace of aging.

  • Danazol (800 mg per day) elongates telomeres in patients with telomere diseases that leads to clinical improvement. (Danazol Treatment for Telomere Diseases NEJM May 19, 2016. 1922-31).  This is mediated through the estrogen-responsive element in the promoter of the TERT.  Postmenopausal women who received hormone-replacement therapy have longer telomeres.

SIMONE TEN POINT PLAN To Decrease Your Risk of Cancer and Heart Disease…and Aging:

Point 1. NUTRITION.

  • Maintain ideal weight. Decrease calories.

  • Eat low-fat, low-cholesterol diet: Fish, Poultry, Skimmilk products, Eliminate red meats, lunch meats. Limit oils and fat.

  • Eat lots of fiber: 25 – 30 grams per day. Cereals, fruits, vegetables. A supplement may be needed.

  • Supplement diet with certain vitamins & minerals in dosages & combinationsfor your lifestyle.  They will also help lengthen telomeres:

    • Resveratrol as a supplement 10 mg per day, or can be obtained from raisins, purple grape skin, mulberries, peanuts.

    • N-Acetyl-Cysteine 1800 mg per day

    • Alpha-Tocopherol (Vitamin E) 400 IU per day, or can be obtained from nuts, seeds, apples, seafood, spinach, avocados.

    • CoQ10 200 mg per day

    • Tocotrienol 20 mg to 40 mg per day.  Annatto is a rich source of it found in our orange Simone Super Energy.  Tocotrienols are also in red palm oil and rice.

    • L-Arginine 500 mg per day.

    • Vitamin C 500 mg to 1000 mg per day.

    • Vitamin D3 4000 IU per day, or can be obtained from cod liver oil, herring, catfish, cooked salmon and cooked mackerel.

    • Folic Acid 1 mg to 2 mg per day. 

    • Omega 3:  EPA + DHA should be at least 60% or more of the capsule or serving – or can be obtained from cod liver oil, fish, walnuts.

  • Eliminate salt and food additives.

  • Limit barbecue, smoked, and pickled foods.

Point 2. TOBACCO.
Don’t smoke, chew, snuff, or inhale other people’s smoke.
Point 3. ALCOHOL.
Don’t consume, or less than 2 drinks a week.
Point 4. RADIATION.
X-rays only when needed. Use sunscreen and sunglasses.
Point 5. ENVIRONMENT.
Keep air, water, workplace clean. Avoid electromagnetic fields.
Point 6. SEXUAL-SOCIAL, DRUGS, HORMONES. 
Avoid promiscuity, unnecessary hormones and drugs.
Point 7. LEARN the 7 cancer warning signs: 
Lump in breast, non-healing sore, change in wart or mole. Change in bowel / bladder habits. Persistent cough or hoarseness. Indigestion or trouble swallowing. Unusual bleeding.
Point 8. REVIEW ALL RISK FACTORS
Point 9. EXERCISE, RELAX, SPIRITUALITY, SEXUALITY.  
Point 10. EXECUTIVE PHYSICAL

(c) 2017 Charles B. Simone, M.MS., M.D.