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Lawrenceville, NJ (Dr Simone) – People with blood types A, B, or AB have a greater risk for developing coronary heart disease when compared to those with blood type O.

     Blood type AB – 4% of the population – 23% increased risk
     Blood type B – 12% of population – 11% increased risk
     Blood type A – 36% of population – 5% increased risk

The findings are based on an analysis of 62,073 nurses in the Nurses Health Study and 27,428 adults in the Health Professional Follow-up Study. These people were predominantly white, aged 30-75 and followed for at least 20 years.

The mechanism for this increased risk seems to be a genetic inheritance of a non-O blood group. In non-O individuals, plasma levels of clotting factor VIII-von Willebrand factor (vWF) complex are ≈25% higher than group O individuals which confers higher risk. Other studies show that non-O individuals have higher lipid levels (cholesterol, triglycerides) and inflammatory markers, including soluble intercellular adhesion molecule, plasma soluble E-selectin levels, P-selectin levels, and tumor necrosis factor-α. All of these elevated levels of inflammation increase the risk for coronary heart disease.

You can’t change your blood type, but you can decrease your risk by adhering to a healthy lifestyle as per our Ten Point Plan (Cancer and Nutrition).


(c) 2017 Charles B. Simone, M.MS., M.D.