October 10, 2015 – Updated 2022

We do not diagnose disease or recommend a dietary supplement for the treatment of disease. You should share this information with your physician who can determine what nutrition, disease and injury treatment regimen is best for you.  You can search this site or the web for topics of interest that I may have written (use Dr Simone and topic).  

“We provide truthful information without emotion or influence from the medical establishment, pharmaceutical industry, national organizations, special interest groups or government agencies.”  Charles B Simone, M.MS., M.D.



Lawrenceville, NJ (Dr Simone) – The FLU season is upon us again. 
Q.  What is the flu?
More than 200 viruses cause influenza and influenza-like illness infecting the airways and produce symptoms that include fever, cough, sore throat, headache, muscle aches and fatigue.  The “flu” commonly occurs in the autumn/winter and is usually self-limiting and can last 1-2 weeks.  Influenza is contagious and is spread from person-to-person by droplets produced when an infected individual coughs or sneezes.  Complications include secondary bacterial infections like otitis media (ear infections) and pneumonia.

Q.  Does the flu vaccine work (does it prevent the flu)?
At best, flu vaccines might be effective against only influenza A and B, which represent about 10% of all circulating viruses that cause the flu like syndrome. 
After reviewing data compiled from the Cochrane Collaboration and the Lancet Infectious Diseases journal (http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70295-X/abstract ) does the flu vaccine work?

​Not in Babies: 51 studies involving 294,000 children aged 6 -24 months found there was “no evidence that injecting [them] with a flu shot was any more effective than placebo.”  In children older than 2 years, it was only effective 33% of the time in preventing the flu. [Cochrane Database of Systemic Reviews. 2 (2008)].

Not in Adults: 48 reports included 66,000 adults: “Vaccination only reduced the risk of influenza infection by 6% and reduced the number of missed worked days by less than one day (0.16).” Cochrane 1. 2006.

Not in the Elderly: 5707 articles screened, 64 studies used in 98 flu season: “Evidence for protection is lacking.” Lancet and Cochrane


Three-quarters of people who got a flu shot 2018 were not protected against H3N2 flu, the viruses that have caused most flu in what has been one of the most difficult flu seasons in years in the United States, according to the Centers for Disease Control and Prevention.

Scientists at the Centers for Disease Control and Prevention showed that after a few months the flu vaccine was only 50% effective and after 5-6 months was not effective at all. (https://academic.oup.com/cid/article/64/5/544/2758477/Intraseason-Waning-of-Influenza-Vaccine-Protection). Other studies from the US and Europe corroborate this finding.

There was a higher risk of miscarriage for pregnant women who received the flu vaccine during both the 2010-11 and 2011-12 influenza seasons. (https://www.elsevier.com/search-results?query=Miscarriage+flu+vaccine+&labels=all).


Q.  Is the flu vaccine dangerous?
In specific cases, influenza vaccines were associated with serious harms such as narcolepsy and febrile convulsions, and even a neurologic disease called Guillain Barre. 

Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines. The Cochrane reviews show that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies.  

Here is the Medicare data for the flu shot in 2021. This is deaths per day since the shot was given for everyone who got the shot in 2021. The “hump” shouldn’t be there. Neither should the Day 0 deaths.



For comparison, here’s a safer vaccine the PNEU shot given in the same year. Would be a safe vax except for the day 0 deaths (the dot at 900)



Q.  Is thimerosal present in the flu vaccine and, if so, does it pose any risk to patients?
Some flu manufacturers use thimerosal or even mercury itself as a preservative.  http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/VaccineSafety/UCM096228#t3
 Although the FDA indicates that there is no risk at the preservative doses, there is no need for a person to choose a vaccine that contains thimerosal when other vaccines are available without it.

Q.  What is your opinion of the public health concept promoted by the CDC and vaccination advocates in the states that all Americans must be vaccinated to protect the weakest among us from contracting the flu?
Governmental agencies like the FDA and CDC employ scientists but are led by politically appointed people who ultimately approve medicines including the flu vaccine. Scientists should guide our science policies and not politically appointed lay people.  The weakest among us, the very young and the elderly, need the most protection because they contract the most complications, and they are virtually not protected by vaccination.  


Defend Yourself From a Viral Attack

Local governments should implement this PLAN (excerpted with permission)

by Charles B. Simone, M.D.:
Pocket size Manual, 48 pages
ISBN 0-9714574-1-7 (September 2001)

We do not diagnose disease or recommend a dietary supplement for the treatment of disease. You should share this information with your physician who can determine what nutrition and disease treatment regimen is best for you. 

ENHANCE YOUR IMMUNE SYSTEM to Decrease Your Risk of Infection 


Maintain an ideal weight.

No four legged animals, shellfish, or dairy products unless they are skim or non-fat.

Organic chicken breasts cooked without the skin.

Swimming fish from the ocean, not the farm.

Fruits and vegetables. 

Supplement your diet with certain nutrients in the proper doses, chemical form, and correct ratio of one to another. Take high doses of antioxidants (the carotenes, vitamins C and E, selenium, cysteine, copper, zinc, bioflavonoids), the B vitamins, and calcium with its enhancers: magnesium, potassium bicarbonate, boron, L-lysine, silicon, threonine.   

Your Formula
      Beta CAROTENE*
30 mg (50,000 IU)
      LUTEIN* 20 mcg  
20 mcg  
Vitamin A (retinyl Palmitate) 5,000 IU  
Vitamin D3 (cholecalciferol) 500 IU  
VITAMIN E* (tocopheryl/succinate) 400 IU  
VITAMIN C* (ascorbic acid) 350 mg  
Folic acid  400 mcg  
Vitamin B1 (thiamin) 10 mg  
Vitamin B2 (riboflavin) 10 mg  
Niacin (niacinamide) 40 mg  
Vitamin B6 (pyridoxine HCl) 10 mg  
Vitamin B12 (cyanocobalamin) 18 mcg  
Biotin 150 mcg  
Pantothenic acid 20 mg   
SELENIUM* (organic) 200 mcg  
COPPER(cupric oxide) 3 mg  
ZINC* (zinc gluconate) 30 mg  
Iodine (potassium iodide) 150 mcg  
Potassium (potassium chloride) 30 mg  
CHROMIUM* (organic) 125 mcg  
Manganese (gluconate) 2.5 mg  
Molybdenum (proteinate) 50 mg  
Inositol 10 mg  
PABA (para-aminobenzoic acid) 10 mg  
Choline (bitartrate) 10 mg  
L-CYSTEINE* (L-cysteine HCl) 20 mg  
L-Arginine HCl 5 mg  



Tobacco – Do not smoke, chew, snuff, or inhale other people’s smoke

Alcohol – less than 2 drinks per week

Walking – briskly for 30 minutes five times a week.

Modify stress


WASH HANDS AND FACE often with soap. Droplets laden with viruses from people who speak to you travel at least three feet from their mouths. Keep your distance and don’t shake hands. Soap and water is the best.  Next best is a hand sanitizer with at least 70% alcohol and not hand sanitizers that contain benzalkonium chloride because it may merely reduce the growth of germs rather than kill them.


Sneezing 40,000 per sneeze
Bowel Evacuation 20,000 per event
Vomiting 1,000 per event
Coughing 710 per cough
Talking 36 per 100 words
Coughing is more common than Sneezing

DECREASE MUCUS PRODUCTION AND MEMBRANE SWELLING by avoiding: dairy products, citrus, dust mites, air flight, low pressure barometric pressure (rain, snow, overcast weather).  Pre-menses swells membranes. 

Dust mites live in mattresses, pillows, sheets, blankets, rugs, window dressings, etc.  They wait for warm moist bodies – you – and come out by the hundreds of thousands on you, defecate and this causes the allergic reaction that swells sinus exit ports. Use hot water to wash.  Cover your mattress and pillows with dust mite covers.

BLEACH – Diluted bleach decontaminates skin and inanimate objects. Viruses generally die on inanimate objects after 12 hours.

Make diluted bleach solution (0.5%) to decontaminate skin from chemicals or biologicals. Even anthrax spores, the most stable of all biologicals, are killed by this solution.  Leave this diluted bleach on the skin for about 10-15 minutes.  Make this solution by mixing 1 part undiluted bleach from the bottle with 9 parts of water (bleach from the bottle is 5.25%).  Make a new solution every day you need it.  Avoid eye contact.

SINUS HYGIENE – Keep sinus exit ports open:


1) Saline nasal flushes every 30 to 45 minutes – this has antiviral effects (https://www.nature.com/articles/s41598-018-37703-3) and promotes mucus flow so that viruses and bacteria can’t lodge.  Insert the spray tip in the nostrils perpendicular to the face and direct it toward the ears to get the spray to the exit ports to open them. 

Using a syringe bulb, flushes with specific concentrations of over-the-counter Iodine (two teaspoons in 6 ounces of water), or Hydrogen Peroxide, or even very dilute Bleach (several drops in 6 ounces of water) can be used in the same manner as nasal saline. All these flushes are particularly useful if you have been in a crowd or in a high traffic and poorly ventilated public restroom.

Povidone Iodine (PVP-I) Oro-Nasal Spray: An Effective Shield for COVID-19 Protection for Health Care Worker (HCW), for all  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026810/
Effect of 1% Povidone Iodine Mouthwash/Gargle, Nasal
and Eye Drop in COVID-19 patient  file:///C:/Users/mail/Downloads/176-Article%20Text-335-2-10-20210102.pdf

The American Dental Association Council on Dental Therapeutics has designated 0.1% sodium hypochlorite a ‘mild antiseptic mouth rinse’ and suggested its use for direct application to mucous membranes. Dilute sodium hypochlorite has no contraindications. Its high degree of safety permits frequent and broad usage by both dentists and patients.

Effects of 0.05% sodium hypochlorite oral rinse on supragingival biofilm and gingival inflammation https://www.sciencedirect.com/science/article/pii/S0020653920332937
Sodium hypochlorite (dilute chlorine bleach) oral rinse in patient self-care



Imagine yourself trying to swim up these or any other waterfalls. It is not possible.  So promote mucus flow so that viruses and bacteria can’t swim up and lodge in your sinuses.

2) Steam (10 min every 4 hours) – boil an inch of water in a quart size pot, take it away from the stove, add about 10 drops of Eucalyptus oil, and inhale over the pot with a towel over your head. 

3) Oxymetazoline nasal spray has antiviral effects and is not a banned substance (over-the-counter).  Use as directed. https://journals.sagepub.com/doi/10.2500/ajra.2010.24.3491

4) Prescription steroid nasal spray to keep inflammation down – this requires a Therapeutic Use Exemption approval during sports competitions. Insert the spray tip in the nostrils perpendicular to the face and direct it toward the ears to get the medicine to the exit ports to open them.

5) Hydrate to keep the mucus thin and flowing.  

HYDROGEN PEROXIDE changes the structure of viruses and generates oxygen that kills viruses. Gargle for several minutes with hydrogen peroxide (right from the bottle) twice a day.

ZINC – weekly dose of 70 mg for all ages reduces mortality/morbidity from viruses and bacteria50 mg per day when you are exposed or feel sick.  Also, Zinc Lozenges

1) Brooks WA, et al. Lancet. 2005. 366:999-1004. 2) Bhatnagar S. Lancet. 2007. 369:885-886. 3) Sazawal S et al. Lancet. 2007. 369:927-34. 4) Barnett JB et al. Nutr Rev. 2010 Jan; 68(1): 30–37.

N-ACETYL CYSTEINE – 600 mg twice a day.  N-acetyl cysteine inhibits virus replication and lung inflammation.


VITAMIN C – 2 to 4 grams each day with food.  200 mg of vitamin C per day resulted in an 80% decrease in deaths among severely ill, hospitalized respiratory disease patients.

Hunt C et al. The clinical effects of Vitamin C supplementation in elderly hospitalized patients with acute respiratory infections. Int J Vitam Nutr Res 1994;64:212-19. https://www.ncbi.nlm.nih.gov/pubmed/7814237

VITAMIN D3 – 5,000 IU per day with food, or the dose needed to raise your blood level to about 80 ng/ml.  Vitamin D3 enhances the immune system and also reduces infectivity of SARS-CoV 2 by binding to the viral spike protein thus locking it into a closed position. Steroids have the same effect, but cholesterol increases infectivity.  About 40% of COVID-19 patients with abnormally low levels of Vitamin D3 levels ended up in the ICU or had to be hospitalized.  Vitamin D is fat soluble and accumulates in fatty tissue.  People who are overweight/obese therefore have less Vitamin D3 available in the bloodstream.  

Molecular simulations suggest vitamins, retinoids and steroids as ligands binding the free fatty acid pocket of SARS-CoV-2 spike protein. Toelzer et al. Angewandte Chemie. 19 January 2021.https://doi.org/10.1002/anie.202015639   https://onlinelibrary.wiley.com/doi/10.1002/anie.202015639


QUERCETIN500 mg twice per day (nutrient, over-the-counter) – interferes with the virus binding onto your cells.  Quercetin possesses anti-influenza activity by inhibiting viral entry, viral-cell fusion, viral replication, viral load, and lung inflammation and airways hyper-responsiveness in vivo.  Quercetin has antibacterial, antifungal and antiviral properties.

Wenjiao W, et al. Viruses. 2016. Jan. 8(1):6;  Kinker et al. J Infectious Diseases & Preventive Med 2014 2.2. 

A reduction in total sick days and severity was noted in middle aged and older subjects ingesting 1000 mg quercetin per day for 12 weeks who rated themselves as physically fit (Heinz SA et al. Pharmacol Res. 2010 Sep;62(3):237-42).

Quercetin outperforms Tamiflu – A mouse study showed that quercetin reduced symptoms and gave higher survival rates.  Also, animals treated with Quercetin had half of the virus load in their lungs compared to animals treated with Tamiflu. (Choi HJ, et al. Phytother Res. 2012 Mar;26(3):462-4).

Tamiflu’s chemical structure is similar to Quercetin but different enough to allow it to be patented. Despite all the media attention about Tamiflu, here is what the makers of Tamiflu say in their insert (Nov 2009):

Adults felt better 30 percent faster (1.3 days) than flu patients who did not take TAMIFLU.  Children felt better up to 26 percent faster (1.5 days) than flu patients who did not take TAMIFLU

JET PLANES should use only OUTSIDE AIR for cabin.

(c) 2020 Charles B. Simone, M.MS., M.D.