We do not diagnose disease or recommend a dietary supplement for the treatment of disease. You should share this information with your physician who can determine what nutrition, disease and injury treatment regimen is best for you.  You can search this site or the web for topics of interest that I may have written (use Dr Simone and topic).  

“We provide truthful information without emotion or influence from the medical establishment, pharmaceutical industry, national organizations, special interest groups or government agencies.”  Charles B Simone, M.MS., M.D.

CORONAVIRUS FLU COVID-19

https://bit.ly/2w8Hr6C


 

 

January 24, 2020 Second Interview: Dr Simone discusses How to Prevent the Flu

 


CORONAVIRUS COVID-19 HAS ALREADY MUTATED 

March 5, 2020 – According to scientists in China and published in the National Science Review, coronavirus COVID-19 in China after only a few months has already mutated to a second strain.  The two strains are the S type (30%) and the more aggressive L type (70%).  Coronaviruses are RNA viruses and mutate often when they replicate quickly.  When I was interviewed on NewsMaxTV I explained that a vaccine is made to a specific strain and therefore will be progressively less effective with each succeeding mutation of the virus. 

This is an excellent interview by physicians for physicians:

 

We do not diagnose disease or recommend a dietary supplement for the treatment of disease. Share this information with your physician who can determine what nutrition, disease and injury treatment regimen is best for you.

ACE INHIBITORS, ARBs, IBUPROFEN, THIAZOLIDINEDIONES AND DIABETES MAY CONFER HIGHER RISK FOR COVID-19

 

Lawrenceville, NJ (Dr Charles Simone) – It is known that coronaviruses (SARS-CoV – severe acute respiratory syndrome coronavirus, and SARS-CoV-2) bind to target cells via its host receptor angiotensin-converting enzyme 2 (ACE2) [1]. 

COVID-19 coronavirus attaches and binds to their target cells through ACE2 protein sites on cells of the lung, intestine, kidney, and blood vessels [1]. 

ACE2 receptor sites are increased [2] by :

Ibuprofen,

Anti-hypertension medicines like

ACE (angiotensin-converting enzyme) inhibitors, and

ARBs (angiotensin II type-I receptor blockers),

Thiazolidinediones (used to treat diabetes), and

Having diabetes type 1 and type 2.

The most frequent comorbidities (cerebrovascular diseases, diabetes, hypertension, coronary artery disease) reported so far of patients with COVID-19 are usually treated with angiotensin-converting enzyme (ACE) inhibitors, although this was not indicated in the studies. 

This higher amount of ACE2 will increase infection with COVID-19 and consequently can increase the risk for severe and fatal COVID-19.

Antihypertensive calcium channel blockers do not increase ACE2 and therefore could be an alternate drug. [3].

SPEAK WITH YOUR PRESCRIBING PHYSICIAN

Examples of Angiotensin-Converting Enzyme (ACE) inhibitor

  • Benazepril (Lotensin, Lotensin Hct), 

  • Captopril (Capoten),

  • Enalapril (Vasotec),

  • Fosinopril (Monopril),

  • Lisinopril (Prinivil, Zestril),

  • Moexipril (Univasc)

  • Perindopril (Aceon),

  • Quinapril (Accupril),

  • Ramipril (Altace), 

  • Trandolapril (Mavik).

Examples of Angiotensin II Receptor Blockers (ARBs) include:

  • Azilsartan (Edarbi)

  • Candesartan (Atacand)

  • Eprosartan

  • Irbesartan (Avapro)

  • Losartan (Cozaar)

  • Olmesartan (Benicar)

  • Telmisartan (Micardis)

  • Valsartan (Diovan)

Examples of Thiazolidinediones include:

  • Rosiglitazone (Avandia)

  • Pioglitazone (Actos)

Examples of calcium channel blockers include:

  • Norvasc (amlodipine)

  • Plendil (felodipine)

  • DynaCirc (isradipine)

  • Cardene (nicardipine)

  • Procardia XL, Adalat (nifedipine)

  • Cardizem, Dilacor, Tiazac, Diltia XL (diltiazem)

  • Sular (Nisoldipine)

  • Isoptin, Calan, Verelan, Covera-HS (verapamil) 

[1] Wan Y et al. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. J Virology. 2020; (published online Jan 29). DOI:10.1128/JVI.00127-20

[2] Li XC et al. The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017; 12521-38

[3] Fang L, et al. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respiratory Medicine.3-20

Instead, rely on an empowering plan to protect yourself and your loved ones – go to

FLUhttps://bit.ly/39fGFDz

HOW TO REDUCE YOUR RISK OF CONTRACTING THE FLU? Local governments should implement this PLAN (several steps excerpted with permission)

HOW TO SAVE YOURSELF FROM A TERRORIST ATTACK HOW TO SAVE YOURSELF FROM A TERRORIST ATTACK
by Charles B. Simone, M.D.:Pocket size Manual, 48 pages
ISBN 0-9714574-1-7 (September 2001)

We do not diagnose disease or recommend a dietary supplement for the treatment of disease. You should share this information with your physician who can determine what nutrition and disease treatment regimen is best for you. 

ENHANCE YOUR IMMUNE SYSTEM to Decrease Your Risk of Infection 

Nutrition – Maintain an ideal weight. No four legged animals, shellfish, or dairy products unless they are skim or non-fat. Poultry cooked without the skin. Swimming fish. Fruits and vegetables.  Supplement your diet with certain nutrients in the proper doses, chemical form, and correct ratio of one to another. Take high doses of antioxidants (the carotenes, vitamins C and E, selenium, cysteine, copper, zinc, bioflavonoids), the B vitamins, and calcium with its enhancers: magnesium, potassium bicarbonate, boron, L-lysine, silicon, threonine.              

Simone Antioxidant – Nutrient Supplementation

Carotene               30 mg                    Selenium              200 mcg 

Lutein                    20 mcg                  Copper                  3 mg       

Lycopene              20 mcg                  Zinc                       30 mg

Vitamin A              5500 IU                  Iodine                     150 mcg

Vitamin D              400 IU                    Bioflavonoids       10 mg

Vitamin E             400 IU                    Chromium              125 mcg

Vitamin C             350 mg                   Manganese             2.5 mg

Folic Acid              400 mcg                Molybdenum         50 mg

All B Vitamins                                      L-Cysteine            20 mg

Tobacco – Do not smoke, chew, snuff, or inhale other people’s smoke

Alcohol – less than 2 drinks per week

Walking – briskly for 20 minutes four times a week.

Modify stress

 

WASH HANDS AND FACE often with soap. Droplets laden with viruses from people who speak to you travel at least three feet from their mouths. Keep your distance and don’t shake hands.  Soap and water is the best.  The next best recommended by the Centers for Disease Control and Prevention is a hand sanitizer with at least 60% alcohol and not an alcohol-free hand sanitizer that contains benzalkonium chloride because it may merely reduce the growth of germs rather than kill them.

DROPLET OR AIRBORNE MICROORGANISMS RELEASED FROM VARIOUS ACTIVITIES

ACTIVITY APPROXIMATE PARTICLE COUNT

Sneezing 40,000 Per sneeze

Bowel evacuation 20,000 Per event

Vomiting 1,000 Per event

Coughing 710 Per cough

Talking 36 Per 100 words

Coughing is more common than Sneezing

DECREASE MUCUS PRODUCTION AND MEMBRANE SWELLING by avoiding: Dairy products, citrus, dust mites, air flight, low pressure barometric pressure (rain, snow, overcast weather).  Pre-menses swells membranes. 

Dust mites live in mattresses, pillows, sheets, blankets, rugs, window dressings, etc.  They wait for warm moist bodies – you – and come out by the hundreds of thousands on you, defecate and this causes the allergic reaction that swells sinus exit ports. Use hot water to wash.  Cover your mattress and pillows with dust mite covers.

BLEACH – Diluted bleach decontaminates skin and inanimate objects. Viruses generally die on inanimate objects after 12 hours.

Make diluted bleach solution (0.5%) to decontaminate skin from chemicals or biologicals. Even anthrax spores, the most stable of all biologicals, are killed by this solution.  Leave this diluted bleach on the skin for about 10-15 minutes.  Make this solution by mixing 1 part undiluted bleach from the bottle with 9 parts of water (bleach from the bottle is 5.25%).  Make a new solution every day you need it.  Avoid eye contact.

SINUS HYGIENE – Keep sinus exit ports open with:

Steam (10 min every 6 hours),

Oxymetazoline nasal spray that has antiviral effects (over-the-counter https://journals.sagepub.com/doi/10.2500/ajra.2010.24.3491),

Salt water nasal flushes have antiviral effects (https://www.nature.com/articles/s41598-018-37703-3),

Hydration.

SINUS HYGIENE SINUSITIS https://bit.ly/3aiBUsS

Flush your nose with a nasal saline spray to promote mucus flow so that viruses and bacteria can’t lodge.  Insert the spray tip in the nostrils perpendicular to the face and direct it toward the ears to get the spray to the exit ports to open them.

Use steam with Eucalyptus oil – boil about an inch of water in a quart size pot, take it away from the stove, add about 10 drops of Eucalyptus oil, and inhale over the pot with a towel over your head for about ten minutes four to five times a day. You may use an over-the-counter Oxymetazoline nasal spray (not a banned substance) as directed. You can add a prescription steroid nasal spray to keep inflammation down but this requires a Therapeutic Use Exemption approval during sports competitions. Insert the spray tip in the nostrils perpendicular to the face and direct it toward the ears to get the medicine to the exit ports to open them. Hydrate to keep the mucus thin and flowing.  

HYDROGEN PEROXIDE changes the structure of viruses and generates oxygen that kills viruses. Gargle for several minutes with hydrogen peroxide (right from the bottle) twice a day.

ZINC – weekly dose of 70 mg for all ages reduces mortality/morbidity from viruses and bacteria*.  Also, Zinc Lozenges.  

*1) Brooks WA, et al. Lancet. 2005. 366:999-1004. 2) Bhatnagar S. Lancet. 2007. 369:885-886. 3) Sazawal S et al. Lancet. 2007. 369:927-34.  4) Barnett J, Nutr Rev 2010 Jan 68(1):30-37

N-ACETYL CYSTEINE 600 mg twice a day.

VITAMIN C 2 to 4 gm & VITAMIN D 1000 IU per day.

QUERCETIN 500 mg twice per day (nutrient over-the-counter) – interferes with the virus binding onto your cells.

Quercetin possesses anti-influenza activity by inhibiting viral entry, viral-cell fusion, viral replication, viral load, and lung inflammation and airways hyper-responsiveness in vivo.  Quercetin has strong antibacterial, antifungal and antiviral properties.

Wenjiao W, et al. Viruses. 2016. Jan. 8(1):6; Kinker et al. J Infectious Diseases & Preventive Med 2014 2.2. 

A reduction in total sick days and severity was noted in middle aged and older subjects ingesting 1000 mg quercetin per day for 12 weeks who rated themselves as physically fit (Heinz SA et al. Pharmacol Res. 2010 Sep;62(3):237-42).

Quercetin outperforms Tamiflu – A mouse study showed that quercetin reduced symptoms and gave higher survival rates.  Also, animals treated with Quercetin had half of the virus load in their lungs compared to animals treated with Tamiflu. (Choi HJ, et al. Phytother Res. 2012 Mar;26(3):462-4).

Tamiflu’s chemical structure is similar to Quercetin but different enough to allow it to be patented. Despite all the media attention about Tamiflu, here is what the makers of Tamiflu say in their insert (Nov ’09):

Adults felt better 30 percent faster (1.3 days) than flu patients who did not take TAMIFLU
Children felt better up to 26 percent faster (1.5 days) than flu patients who did not take TAMIFLU

JET PLANES should use only OUTSIDE AIR for cabin.

© 2020 Charles B Simone, M.MS., M.D.; not applicable to the JAMA interview