For many years only the issue of unfiltered blood clots causing a stroke was considered in deciding how to treat a patient with a PFO because the other very important physiological consequences were not considered.
The totally blind person with no perception of light does not have the benefit of the circadian rhythms of night and day. Melatonin can synchronize (entrain) the internal circadian clock for the blind person. Cost of Melatonin: about $45 or less per year per person. Big Pharma drug $60,000 or more per year per person
