by Dr Simone | Oct 27, 2026 | CLOTS, COVID-19, Dehydration, Dr Simone, HEALTHCARE CRISIS, Infections, Inflammation, PLASMAPHERESIS, The Simone Report, THERAPEUTIC PLASMA EXCHANGE (TPE)
Recurrent deep venous thrombosis (DVT) during infectious diseases like COVID-19 happens because the virus triggers a severe systemic inflammatory and procoagulant state. [1, 2]
The mechanisms driving this increased risk are explained through Virchow’s triad (endothelial injury, hypercoagulability, and stasis) combined with specific immune responses: [1, 2]
1. Endothelial Injury and Viral Direct Invasion
2. Hypercoagulability (Overactive Clotting)
3. Venous Stasis
by Dr Simone | Oct 22, 2026 | anesthesia, COVID-19, Dr Simone, Flu, VACCINE
“Close Your Eyes, We’ll Immunize” Program at CHOP (Children’s Hospital of Philadelphia) to vaccinate children against the flu while they are sedated or under anesthesia for a medical procedure – and plans to add COVID-19 and RSV shots.
by Dr Simone | Oct 21, 2026 | DEMENTIA, Dr Simone, GLUCOSAMINE, The Simone Report
Progression to Dementia: Glucosamine use was associated with a 25% higher likelihood that mild cognitive impairment (MCI) would progress to Alzheimer’s disease or related dementias (ADRD).
Mortality Risk: Among patients already diagnosed with ADRD, glucosamine use was linked to a 25% higher mortality risk over a defined period.
by Dr Simone | Oct 16, 2026 | Cancer, Dr Simone, Pope Leo, The Simone Report
Pope Leo never smoked, never had medical problems, and is active. We know that 17% of all lung cancers we see are in people who never smoked but who inhaled second-hand smoke between the ages of 3 and 15 years old. I don’t know if he had this exposure.
His brother has multiple myeloma.
One common denominator for both lung cancer and multiple myeloma is RADON exposure.
by Dr Simone | Oct 1, 2026 | Dr Simone, VETERANS
I SPOKE TO VETERANS ABOUT VARIOUS TOPICS INCLUDING SUICIDE PREVENTION
by Dr Simone | Aug 21, 2026 | Big Pharma, Cancer, CANCER RELATED FATIGUE CRF, CDC, Dr Simone, FDA, Healthcare, HEALTHCARE CORPORATIZATION, Healthcare Costs, HEALTHCARE CRISIS, The Simone Report
RESEARCH IN INDIA HAS EVEN FOUND THAT ONE-TWELFTH OF THE STANDARD NIVOLUMAB DOSE MAY BE EFFECTIVE.
DRUGMAKERS, HOSPITALS, AND PHYSICIANS HAVE FINANCIAL INCENTIVES TO MAINTAIN HIGHER DOSING
ONE ESTIMATE SUGGESTS THE U.S. COULD HAVE SAVED ROUGHLY $31 BILLION IN 2024 BY USING THE LOWEST EFFECTIVE DOSES OF 29 EXPENSIVE CANCER DRUGS.
by Dr Simone | Jul 20, 2026 | DOPAMINE, Dr Simone, LONG COVID BRAIN
Patients with long COVID have described neurologic symptoms like brain fog, memory problems, difficulty concentrating, and lack of motivation. A new study suggests these symptoms may be related to measurable changes in the brain’s dopamine system. The lower levels were in the region of the brain called the striatum, which plays key roles in reward and motivation, movement and motor control, and cognition—the brain’s ability to think and process information.
by Dr Simone | Jul 12, 2026 | Dr Simone, Mönckeberg’s disease
Mönckeberg’s disease calcifies the middle layer of medium and small blood vessels in extremities. It does not cause obstruction generally.
However, it significantly reduces arterial compliance, turning muscular vessels into rigid, non-distensible “pipestems” and can thereby raise blood pressure, heart problems, etc.
by Dr Simone | May 15, 2026 | Dr Simone, Health Policy, Healthcare, HEALTHCARE CORPORATIZATION, Healthcare Costs, HEALTHCARE CRISIS
To restore balance, academic medical centers should refocus on education, research, and public service; protect trainees from purely profit-driven pressures; and promote physician-leaders who remain directly engaged in patient care and teaching.
More than a century after the Flexner Report warned about commercialization in medicine, business priorities again threaten to overshadow the core mission of academic medicine: patient care, education, and scientific discovery.
by Dr Simone | May 11, 2026 | AGING, Anti-Aging, COGNITIVE AGING, DEMENTIA, Dr Simone, Exercise
Aging is often associated with inevitable physical and cognitive decline, but emerging evidence suggests many older adults maintain—or even improve—their function over time. A large longitudinal study published in Yale School of Public Health and reported in the journal Geriatrics found that more than 45% of adults age 65 and older demonstrated improvement in cognitive function, physical function, or both over more than a decade of follow-up.[1]
Researchers identified one major predictor of successful aging: positive beliefs about aging itself. Older adults with more optimistic attitudes toward aging were significantly more likely to improve in cognition and walking speed, a key geriatric “vital sign” strongly associated with disability, hospitalization, falls, and mortality.[1,2]
by Dr Simone | May 8, 2026 | Dr Simone, VAPING
Given rising evidence of pulmonary, cardiovascular, neurologic, and addiction-related harms — especially among youth — public health policy should prioritize prevention of adolescent nicotine exposure, transparent labeling of vaping products, tighter regulation of flavorings and marketing practices, and continued long-term safety research on e-cigarettes.
by Dr Simone | Apr 27, 2026 | Dr Simone, Healthcare Costs, HEALTHCARE CRISIS, PSYCHEDELICS
Psychedelic-assisted therapies, including psilocybin- and MDMA-based interventions, demonstrate promising but preliminary efficacy for certain psychiatric conditions, particularly treatment-resistant depression and post-traumatic stress disorder. However, the current evidence base is derived predominantly from small, highly controlled clinical trials with carefully selected participants, intensive therapeutic support, and methodological limitations (including challenges with blinding and expectancy effects).
Until such evidence is established, first-line treatment should remain evidence-based pharmacotherapy and psychotherapy with well-characterized efficacy and safety profiles.
by Dr Simone | Apr 22, 2026 | ANTICOMPETITIVE MERGERS, Big Pharma, Dr Simone, Healthcare Costs, HEALTHCARE CRISIS
U.S. antitrust policy should be strengthened to address anticompetitive mergers in the pharmaceutical sector, particularly “killer acquisitions” that eliminate emerging competition. This includes lowering reporting thresholds in highly concentrated health care markets, requiring the inclusion of intangible assets such as patents in merger evaluations, and applying heightened scrutiny to transactions involving overlapping products. Regulators, including the Federal Trade Commission and the Department of Justice, should also require enforceable commitments to continued product development and post-merger transparency. These reforms would help preserve competition, promote innovation, and protect patients from high prices and reduced access to essential therapies.
by Dr Simone | Apr 2, 2026 | ACE2, Big Pharma, Bioweapon, CDC, CORONAVIRUS, COVID-19, Dr Simone, FDA, HEALTHCARE CRISIS, VACCINE
The Coronavirus and mRNA patents and medical papers evolved from 1989 onward. In 1999 Bill Gates had to re-brand himself and started Global Alliance for Vaccines and Immunization to market vaccines.
In Feb 2011, he “specifically requested” Epstein’s help. Epstein created a pre-COVID operational structure — financialized, globally coordinated, and partially integrated with Pentagon biodefense systems — that he built, staffed, and rehearsed. Epstein put himself at the junction of these systems, linking philanthropic capital, Wall Street finance, global health governance, and Pentagon biosecurity research.
by Dr Simone | Mar 12, 2026 | “Shared clinical decision-making”, Advisory Committee on Immunization Practices, CDC, Dr Simone, FDA, Healthcare, HEALTHCARE CRISIS, mRNA COVID shot, The Simone Report
In principle, shared clinical decision-making aims to make care more individualized and collaborative. In practice, however, it can place complex judgments about uncertain evidence into the hands of patients who may have limited time, information, or technical expertise to fully evaluate the choices.
by Dr Simone | May 26, 2025 | Big Pharma, BILL OF RIGHTS, Bioweapon, Cancer, CDC, Children, CORONAVIRUS, COVID-19, Dr Simone, Dr Simone Report, FDA, FIFTH AMENDMENT, FOURTEENTH AMENDMENT, Innate Immunity, Myocarditis, VACCINE
Because of President Trump’s Restoring Gold Standard Science Executive Order (binding within 30 days), I am convinced that he will adhere to the scientific and legal definition of a vaccine – as defined by the CDC, FDA, NIH, NIAID, NCI, U.S Patent Office, and Ninth Circuit Court – A VACCINE MUST PREVENT THE DISEASE AND PREVENT ITS TRANSMISSION – the mRNA gene therapy INJECTION DOES NEITHER – a salient fact arbitrarily and capriciously ignored by FDA’s Drs Prasad and Makary thus defying President Trump’s Executive Order, the Ninth Circuit’s ruling, agencies and Institutes, and thereby putting 100-200 million Americans at risk.
Regardless of age, the COVID shots will not help anyone with other risk factors because it will not prevent them from getting COVID nor will it prevent them from transmitting COVID.
The harm from these shots is real and the shots cannot be justified given the low fatality rate of COVID. This gene therapy must have different guidance and thresholds for market approval.
Since COVID-19 injections are not vaccines, the precedent set by Jacobson v. Massachusetts, allowing compelled vaccination, is irrelevant.
Instead, the Supreme Court’s ruling in Cruzan v. Director, Missouri Department of Health, which protects the right to refuse medical treatment, would apply. The federal government lacks a basis to mandate COVID-19 injections for employment or service, and the mandated childhood COVID-19 injections for school violates the right to refuse medical treatment recognized in Cruzan.
by Dr Simone | May 14, 2025 | Dr Simone, Dr Simone Report, Drugs, FDA, Healthcare, Healthcare Costs, TELEHEALTH
Current rules from the FDA apply to drug companies’ ads, requiring them to show risks. But telehealth companies aren’t held to the same standards — even when they promote the same drugs. That could mislead patients.
Are doctors favoring drugs from partner companies?
Are patients being properly evaluated?
What exactly are the companies paying each other for?
Is the Anti-Kickback Statute (AKS) being violated?
by Dr Simone | May 1, 2025 | Artificial Intelligence, Charles B. Simone, Dr Simone, Dr Simone Report, Grok, Medicine
Mr Elon Musk – Your X men arbitrarily and capriciously suspended my account (@DrSimone joined Feb 2009, 5218 posts) even though your own Grok says they have it wrong and I did not violate any X rules. Two days after I sent Grok’s comprehensive analysis to your X men, they completely blocked me from using Grok. Please reinstate.
“Based on this [Grok’s] analysis, the content does not appear to violate X’s rules as they are generally understood. It’s a critical opinion piece with references, not a clear breach like hate speech or a scam. X tends to allow robust debate, especially on topics like health policy, unless it crosses into specific prohibitions” – Grok
https://tinyurl.com/2tep4mae
by Dr Simone | Apr 1, 2025 | CDC, Charles B SimoneMD, Children, CORONAVIRUS, COVID-19, Dr Simone, Dr Simone Report, FDA, The Simone Report, VACCINE
In a decision that has ignited fierce debate, Susan Monarez, PhD, Acting Director of the U.S. Centers for Disease Control and Prevention (CDC), recently endorsed the Advisory Committee on Immunization Practices’ (ACIP) recommendation to vaccinate children aged 5-11 against COVID-19 with the Pfizer-BioNTech pediatric vaccine. Announced in late 2021 and reinforced through ongoing CDC guidance, this move extends vaccine recommendations to over 28 million children nationwide, authorizing providers to begin administering the shots. At first glance, it might seem like a standard public health strategy to combat a global pandemic. Yet, a deeper dive reveals a troubling rift between this policy and the scientific evidence—a rift that Monarez and the ACIP appear to have overlooked, potentially undermining the very mission they are sworn to uphold.
by Dr Simone | Mar 3, 2025 | Breast Cancer, Cardiovascular Disease, COGNITIVE AGING, DEMENTIA, Dr Simone, Microplastics
Microplastics are tiny plastic particles, less than 5mm in size, that enter the body and cause harm.
